![]() Without proper levels of these hormones, many bodily functions are negatively affected. These are important regulators of water retention, blood pressure and potassium levels in the blood. Addison's disease occurs when the adrenal glands are not able to produce adequate quantities of hormones, including cortisol (glucocorticoid) and aldosterone (mineralocorticoid). Immune-mediated destruction of the adrenal gland is the most likely and common cause of Addison's disease. This means the immune system is malfunctioning and mistakenly attacking healthy tissue, in this case, the adrenal glands.Īddison's disease can also be caused by a tumour in the dog's adrenal gland and other processes that destroy the adrenal glands such as infections. The most common cause of Addison's disease is an autoimmune reaction that targets the adrenal glands. ![]() Cortisol has many functions in the dog, but one of its responsibilities relates to handling stress and emergencies. The adrenal glands are located near the kidneys (one on each side of the body) and produce several different hormones, including cortisol. Addison's disease is an endocrine disorder that affects the adrenal glands.
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